Top 5 Dangers of Kratom Abuse | The Summit Wellness Group (2022)

Even though kratom has a reputation as “safe and natural,” it is actually very dangerous. A few of the risks of using kratom include overdose, deadly drug interactions, and a variety of possible health risks due to contamination. We take a detailed look at each of the top five dangers of kratom use below.

We’ve seen a large uptick in clients admitting to our drug rehab in Atlanta, GA with serious kratom addictions. Make no mistake, this is a very dangerous drug. If you or someone you know is ready to get help, we highly recommend reading our 3 step guide to finding the best rehab.

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  • Last Updated on September 15th, 2021

Kratom Danger #1 – Overdoses

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Contrary to popular belief, it is possible to overdose on kratom. Terms used to describe kratom, such as “all-natural” or “herbal,” mask the nature of the active ingredients which produce effects similar to stimulants and opioids depending on the dose consumed. While the neurotoxic or fatal doses have not been firmly established in humans, there areconfirmed reportsof fatalities where kratom was the only drug present in the body.

With kratom use in the United States on the rise, there has also been a significant increase in the incidence of overdoses.Between 2011 and 2017in the United States, there were 1,807 cases of Kratom exposure which had been called into Poison Control Centers. Of these, 65% were reported between 2016 and 2017. This indicates the use rates spiked drastically during this time.

31.8% of these cases resulted in admission to a hospital. 51.9% resulted in serious medical consequences. From these particular cases, nine deaths have involved kratom and other drugs. Two deaths resulted from kratom usealone. These two deaths are not the only ones as there have been dozens of deaths in the US that involved kratom.

Kratom Danger #2 – Serious Health Risks

While kratom is rumored to be harmless, there are a number of serious risks associated with regular use. The exact causes of the dangers of kratom use are not well understood. It is clear, however, that kratom poses a threat to several vital organs, particularly the liver, kidneys, heart, and brain. These risks include, but are not limited to:

  • Intrahepatic Cholestasis. A type of acute liver damage that is most commonly seen during pregnancy. It results from a blockage or backup of bile in the liver which impairs function. Symptoms include jaundice (yellow of the skin or whites of eyes), severe itching, very dark urine, pale or gray stool, and pain in the upper right abdomen.
  • Drug Induced Liver Injury. A spectrum of different types of acute liver damage caused by drug use. The specific symptoms can be diverse depending on the drug in question. In the case of kratom, cholestasis is the main outcome observed. The National Institutes of Health have given kratom a Hepatotoxicity Score B, which they define as “likely cause of clinically apparent liver injury.”
  • Hyperbilirubinemia. Results from an underlying condition (such as hepatic cholestasis). It is the result of too much bilirubin in the blood due to poor liver function. This can cause jaundice, decreased appetite, and lethargy.
  • Tonic-Clonic (Grand Mal) Seizure. These types of seizures are characterized by a loss of consciousness and powerful muscle contractions, which may sometimes be violent. The exact way that kratom can cause seizures is unknown, but there is a correlation between the two.
  • Posterior Reversible Encephalopathy Syndrome (PRES). Typically drug-induced (from methamphetamines). This can result in a severe headache, disorientation, visual disturbances, and aphasia (inability to generate or understand speech). It can be due to vasogenic edema, which is a buildup of fluid between brain cells that leads to many different problems depending on where in the brain it occurs.
  • Brain Lesions / Focal Epilepsy. The exact causes are unknown, but recurring petit mal and grand mal seizures have been attributed to kratom use. Petit mal seizures are characterized by sudden disorientation and brief loss of consciousness. Grand mal involves a loss of consciousness and sometimes violent muscle contractions.
  • Tachycardia. Increased heart rate and blood pressure. There are several different types of tachycardia, some more dangerous than others. All types can increase the risk of stroke or heart failure. Symptoms include feeling dizzy or lightheaded, heart palpitations, shortness of breath, or chest pain.
  • Torsades de Pointes. A distinct form of tachycardia, it presents with a very recognizable ECG signature. May lead to ventricular fibrillation, which is life threatening.

The lack of regulation for products containing kratom is concerning. There is no enforcing body in place to monitor the quality, potency, or safety of kratom sold. This means that there is no telling what else may be present in kratom. In 2018, there was a serious outbreak of salmonella in the US as a direct result of nonexistent regulation measures (see Danger #5 – Contaminants section below for more information).

Top 5 Dangers of Kratom Abuse | The Summit Wellness Group (4)

Kratom Danger #3 – Dangerous Drug Interactions

There are many potential drug-drug interactions that may occur with kratom. While there have not yet been any studies done on drug-drug interactions in humans, there are many cases where death or serious side effects occurred when kratom was used alongside other drugs. The exact interactions which may have occurred are unclear, but the results are not desirable. Some of these potential drug interactions include, but are not limited to:

  • Zopiclone (Zimovane), Citalopram (Celexa), Lamotrigine (Lamictal): Used in tandem with kratom which resulted in a fatality. Blood levels of the three other drugs were well within the therapeutic range, indicating no abuse was occurring. The post-mortem levels of kratom metabolites were quite high, indicating heavy use.
  • Vyvanse: In this case, there was no history of epilepsy. After using kratom and Vyvanse together, the subject started having both tonic-clonic and absence seizures. Upon discontinuing kratom use, the seizures ceased.
  • Seroquel & Adderall: The patient was presenting with multiple symptoms of PRES (see above) after tandem use of prescription medications and kratom. CT scan showed results consistent with vasogenic edema.
  • Paxil & Lamictal: The subject was found unresponsive by his family after a T-C seizure at home. EMS were called but were unable to resuscitate. Subsequent autopsy revealed that he had suffered heart attack, pulmonary embolism, and brain hemorrhage before finally succumbing to hypoxia.
  • Modafinil (Provigil): After use with Kratom, the subject suffered a T-C seizure.

Additional complications arise when someone uses kratom while pregnant. Again, since so little is understood about kratom’s mechanism of action, it is unwise to use it at all, and especially when pregnant. There have beenconfirmed cases of children being born addicted to kratom and experiencing withdrawal symptoms immediately after birth. If you or a loved one has been using kratom, it is recommended to enter a detox center in Atlanta to safely and comfortably make it through the withdrawal process.

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Kratom Danger #4 – Lack of Legal Regulations

Kratom is currently still legal at a Federal level, but this has been a back-and-forth issue over the years. Beginning in 2014, the FDA posted several notices which made it illegal to import kratom as a dietary supplement(FDA Import Alert 54-15). Invoking theFederal Food, Drug, and Cosmetics Act – Adulteration, Section 402(f)(1)(B)the agency has claimed: “there is inadequate information to provide reasonable assurance that such ingredient (kratom) does not present a significant or unreasonable risk of illness or injury.” This led to three seizures of massive stockpiles of kratom products by US Marshals in 2014and 2016which were valued at over $5.5 million total.

The DEA and Department of Justice didattempt to include kratom as a Schedule 1 drug in 2016with two separate proposed rules. This was met with a massive public backlash. The action was delayed pending further research. Several states have taken it into their hands to make kratom illegal, including Alabama, Arkansas, Indiana, Rhode Island, Vermont, and Wisconsin. It is illegal in these states to possess, purchase, or use kratom. There is also pending state-level legislation that, if unchallenged, will result in kratom becoming illegal or regulated in the near future. States with currently pending legislation include Michigan, Ohio, New York, New Jersey, Georgia, Mississippi, Missouri, and Kansas. Several other states have imposed age restrictions on kratom purchases. Several counties scattered throughout the country have made kratom possession illegal.

The FDA has an active program under the MedWatch umbrella to compile reports of kratom-related issues from health care workers or from kratom users themselves. If you would like to report personal adverse reactions to kratom,you can fill out a MedWatch Volunteer Reporting Form. Until a substantial number of controlled studies on kratom have been completed, the best way to contribute and inform policy is to share your experiences. If you or a loved one has been struggling with kratom addiction and are trying to quit, it is recommended to enter an Atlanta inpatient rehab center.

Kratom Danger #5 – Contamination

In 2018, there wasa massive multi-state salmonella outbreakin which kratom was implicated. There were 199 reported infections in 41 states, and over 70 people were hospitalized.The FDA and CDC performed an investigationand traced the source to contaminated kratom powder, tablets, and tea with no common supplier or distributor identified.

Several companies that sold kratom products performed voluntary recalls. On April 2, 2018,the FDA ordered a mandatory recallof any Kratom products supplied by Triangle Pharmanaturals LLC. There wereseveral different strainsof salmonella found, including salmonella Javiana, Thompson, Okatie, Weltevreden, and Heidelberg.

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FAQs

What organs are affected by kratom? ›

Sometimes, kratom use may lead to severe breathing issues, liver damage, kidney failure, seizures, coma and death. Between July 2016 and December 2017, it played a role in at least 91 overdose fatalities, according to the Centers for Disease Control and Prevention.

How common are seizures with kratom? ›

There has even been a report of kratom use associated with spontaneous intracranial hemorrhage. However, seizures are common and have been reported after single-substance exposure with an incidence of 6.1%2 to 9.6%4 in the United States.

What medications does kratom interact with? ›

To date several case studies of drug interactions with Kratom have been reported that relate to its CNS depressant effects. Both additive and synergistic effects are observed if Kratom is used with benzodiazepines, barbiturates, alcohol, opioids, antidepressants, anxiolytics, and other CNS-active drugs [18].

Why does kratom cause seizures? ›

Tatum et al. reported that kratom use may be related to structural magnetic resonance imaging (MRI) changes in the brain and that its chronic use may result in recurrent seizures requiring treatment with antiepileptic medications [5].

What does kratom do to the heart? ›

First, kratom's most common adverse cardiovascular effects include tachycardia and hypertension. And second, kratom use may affect the cardiac rhythm in a dose-dependent manner.

How hard is kratom on the liver? ›

The onset of injury is usually within 1 to 8 weeks of starting regular use of kratom powder or tablets, with symptoms of fatigue, nausea, pruritus and dark urine followed by jaundice. The pattern of liver injury is typically cholestatic or mixed, and it can be severe with serum bilirubin levels rising above 20 mg/dL.

Can kratom cause brain lesions? ›

Kratom works as a stimulant but at high doses it has sedative/anti-nociceptive effects. Kratom abuse may be associated with structural brain lesions on MRI.

What receptors do kratom bind to? ›

We found that kratom has a strong bind to mu-opioid receptors, comparable to scheduled opioid drugs.

Can kratom cause respiratory problems? ›

Kratom is used for recreation, analgesia, opiate addiction, withdrawal prevention, and as a suicidal agent. With the recent increase in its availability and use, more cases with Kratom related toxicities have been reported associating it with respiratory depression, non-cardiogenic pulmonary edema, and death.

Is kratom good for the body? ›

Kratom has many mood-enhancing effects. Reports show that kratom is an effective treatment for opioid addiction. It has been proven to help alleviate the withdrawal symptoms of morphine and ethanol. Other studies show that kratom has potential as an antidepressant and a hunger suppressant.

What are the health benefits of kratom? ›

At low doses, kratom acts as a stimulant, making users feel more energetic. At higher doses, it reduces pain and may bring on euphoria. At very high doses, it acts as a sedative, making users quiet and perhaps sleepy. Some people who practice Asian traditional medicine consider kratom to be a substitute for opium.

What class of drug is kratom in? ›

Milham, is to make kratom a Schedule II drug — a classification by the Drug Enforcement Administration that's applied to medications “with a high potential for abuse, with use potentially leading to severe psychological or physical dependence.”

Does kratom cause brain swelling? ›

Glatter says side effects of kratom include seizures, dangerously high blood pressure, damage to liver and kidneys, swelling of the brain, breathing problems, and cardiac arrest. The chances of these problems are even higher when people use kratom with alcohol or with other drugs, he says.

Can kratom cause chest pain? ›

Other serious kratom side effects include: Cardiac issues, such as heart attack, abnormal heart rhythms and high blood pressure.

What is Mitragynine found in? ›

Mitragynine is an alkaloid found in the leaves of the South East Asian treeMitragyna speciosa. Kratom leaves are chewed, smoked, or consumed in tea. Leaves from this tree have traditionally been used for both their stimulant properties and as an opium substitute.

Does kratom help with inflammation? ›

The main active ingredients of kratom are the alkaloids mitragynine and 7-hydroxymitragynine. There is evidence that these alkaloids can have analgesic (pain relieving), anti-inflammatory, or muscle relaxant effects. For this reason, kratom is often used to ease symptoms of fibromyalgia.

What is red kratom used for? ›

Red Bali Kratom is great for treating severe pains and inducing euphoria. Apart from those uses, you can use this Kratom strain for a lot of other purposes – its availability makes it a popular strain. Because the Red Bali Kratom is on a large-leafed strain of the Kratom tree, you can easily discover and harvest it.

Can kratom cause heart damage? ›

Other serious kratom side effects include: Cardiac issues, such as heart attack, abnormal heart rhythms and high blood pressure. Encephalopathy (brain disease).

Is kratom good for the body? ›

Kratom has many mood-enhancing effects. Reports show that kratom is an effective treatment for opioid addiction. It has been proven to help alleviate the withdrawal symptoms of morphine and ethanol. Other studies show that kratom has potential as an antidepressant and a hunger suppressant.

Can kratom cause respiratory problems? ›

Kratom is used for recreation, analgesia, opiate addiction, withdrawal prevention, and as a suicidal agent. With the recent increase in its availability and use, more cases with Kratom related toxicities have been reported associating it with respiratory depression, non-cardiogenic pulmonary edema, and death.

Does kratom cause brain swelling? ›

Glatter says side effects of kratom include seizures, dangerously high blood pressure, damage to liver and kidneys, swelling of the brain, breathing problems, and cardiac arrest. The chances of these problems are even higher when people use kratom with alcohol or with other drugs, he says.

What class of drug is kratom in? ›

Milham, is to make kratom a Schedule II drug — a classification by the Drug Enforcement Administration that's applied to medications “with a high potential for abuse, with use potentially leading to severe psychological or physical dependence.”

Does kratom help with inflammation? ›

The main active ingredients of kratom are the alkaloids mitragynine and 7-hydroxymitragynine. There is evidence that these alkaloids can have analgesic (pain relieving), anti-inflammatory, or muscle relaxant effects. For this reason, kratom is often used to ease symptoms of fibromyalgia.

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